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\n\n\n\nThe term inflammatory syndromes encompasses a broad group of conditions in which chronic inflammation is the central pathophysiological mechanism, either as the primary disease process or as a persistent systemic state associated with another condition.<\/p>\n\n\n\n
This category includes chronic systemic inflammation related to metabolic syndrome, obesity-associated inflammation, persistent inflammatory syndromes following infection, such as Long COVID and post-viral inflammation, and other treatment-resistant inflammatory conditions.<\/p>\n\n\n\n
Chronic inflammation, also known as \u201cinflammaging,\u201d when associated with ageing, forms a common biological background to a remarkably wide range of modern diseases, including cardiovascular disease, type 2 diabetes mellitus, neurodegenerative conditions and even certain forms of cancer.<\/p>\n\n\n\n
Its management cannot be limited to pharmacological suppression alone. It also requires interventions that address the underlying biological causes.<\/p>\n\n\n\n
Chronic systemic inflammation is characterised by persistently elevated levels of inflammatory markers and cytokines, including CRP, IL-6, TNF-\u03b1 and IL-1\u03b2, which cause cumulative damage to multiple organs and systems over time.<\/p>\n\n\n\n
Unlike acute inflammation, which is necessary and beneficial, chronic inflammation represents a form of persistent immune dysregulation. The immune system remains activated even in the absence of an active infection or injury that would justify such a response.<\/p>\n\n\n\n
Oxidative stress is an integral feature of chronic inflammation. The reactive oxygen species generated during the inflammatory response aggravate tissue injury, impair mitochondrial function and weaken the body\u2019s natural anti-inflammatory mechanisms.<\/p>\n\n\n\n
This self-perpetuating cycle of inflammation and oxidative stress sustains the chronic pathological state and makes therapeutic intervention more difficult.<\/p>\n\n\n\n\n\n\n\n
The ability of hyperbaric oxygen therapy to reduce systemic inflammatory markers is one of the most consistent findings in the scientific literature.<\/p>\n\n\n\n
Studies across a range of clinical indications have reported significant reductions in CRP, IL-6 and TNF-\u03b1 following courses of hyperbaric oxygen therapy. These findings suggest a systemic anti-inflammatory effect that extends beyond its local action.<\/p>\n\n\n\n
In Long COVID specifically, emerging clinical studies have reported improvements in neurological, cognitive and systemic symptoms among patients who received hyperbaric oxygen therapy, alongside reductions in inflammatory biomarkers.<\/p>\n\n\n\n
The activation of antioxidant enzymes, including superoxide dismutase (SOD), catalase and glutathione peroxidase (GPX), during a course of treatment directly counteracts the self-perpetuating cycle of inflammation and oxidative stress.<\/p>\n\n\n\n
In inflammatory syndromes, hyperbaric oxygen therapy acts as a biological anti-inflammatory intervention that complements, rather than replaces, pharmacological treatment.<\/p>\n\n\n\n
Its value lies in addressing the underlying pathophysiological mechanism\u2014the interaction between inflammation and oxidative stress\u2014rather than merely alleviating symptoms.<\/p>\n\n\n\n
The suppression of inflammatory cytokines through inhibition of NF-\u03baB signaling reduces systemic inflammation, while the activation of antioxidant enzymes helps interrupt the cycle of oxidative stress.<\/p>\n\n\n\n
At the same time, improved mitochondrial function restores energy production in cells functioning under conditions of chronic inflammation.<\/p>\n\n\n\n
For conditions such as Long COVID, an initial treatment course typically consists of 20 to 40 sessions and may be repeated depending on the patient\u2019s response, always under medical supervision.<\/p>\n","protected":false},"excerpt":{"rendered":"
What Are Inflammatory Syndromes? The term inflammatory syndromes encompasses a broad group of conditions in which chronic inflammation is the central pathophysiological mechanism, either as … <\/p>\n