Immune dysregulation disorders are pathological conditions in which the body\u2019s natural immune-regulatory mechanisms fail to maintain the balance between immune defence and self-tolerance. When these mechanisms break down, the immune system loses its ability to distinguish between external threats and the body\u2019s own tissues, leading to autoimmunity.<\/p>\n\n\n\n
A central element of this imbalance is dysfunction of regulatory T lymphocytes (Tregs). Tregs act as the immune system\u2019s \u201creferees\u201d; when their function is impaired or their numbers are reduced, pro-inflammatory lymphocytes may act without adequate control.<\/p>\n\n\n\n
Treg dysfunction is a common feature across a remarkably broad spectrum of autoimmune diseases, from lupus and rheumatoid arthritis to inflammatory bowel disease and autoimmune neuropathies.<\/p>\n\n\n\n
Immune regulation depends on a complex network of cellular and molecular interactions. Regulatory T lymphocytes produce anti-inflammatory cytokines, including IL-10 and TGF-\u03b2, which help suppress autoimmune responses.<\/p>\n\n\n\n
At the same time, signalling pathways such as mTOR, which are directly influenced by cellular oxygenation, regulate the balance between different T-lymphocyte subtypes.<\/p>\n\n\n\n
This relationship between cellular oxygen levels and immune balance is biologically important. Oxygenation does not affect only cellular metabolism; it also directly influences immune programming. Under hypoxic conditions, T cells are driven towards pro-inflammatory phenotypes, whereas adequate oxygenation favours the development of regulatory phenotypes.<\/p>\n\n\n\n
Cellular and animal studies have shown that hyperoxygenation through hyperbaric oxygen therapy may increase both the activity and number of regulatory T lymphocytes, inhibit the differentiation of Th17 cells and restore immune balances disrupted by chronic inflammation or autoimmune activation.<\/p>\n\n\n\n
These findings have also been reported in clinical studies involving patients with multiple sclerosis, Crohn\u2019s disease and rheumatoid arthritis.<\/p>\n\n\n\n
The potential of hyperbaric oxygen therapy to restore the Treg\/Th17 balance represents one of the most promising emerging findings in scientific literature, particularly because this balance is a common therapeutic target across almost all autoimmune diseases.<\/p>\n\n\n\n
In immune dysregulation disorders, hyperbaric oxygen therapy targets a fundamental biological mechanism underlying autoimmunity: impaired immune regulation that allows the immune system to attack the body\u2019s own tissues.<\/p>\n\n\n\n
By restoring the Treg\/Th17 balance, inhibiting NF-\u03baB signalling and promoting anti-inflammatory cytokine activity, it may create a biological environment that favors immune tolerance rather than autoimmune attack.<\/p>\n\n\n\n
This intervention is always used as an adjunct, supporting rather than replacing pharmacological immunomodulation.<\/p>\n\n\n\n
The treatment course is individualised according to the underlying immune disorder. It typically consists of 20 to 40 sessions and is always carried out under rheumatological or immunological supervision.<\/p>\n","protected":false},"excerpt":{"rendered":"
Immune Dysregulation Disorders Immune dysregulation disorders are pathological conditions in which the body\u2019s natural immune-regulatory mechanisms fail to maintain the balance between immune defence and … <\/p>\n